Cargando…
Possible mechanism of metabolic and drug resistance with L-asparaginase therapy in childhood leukaemia
L-asparaginase, which hydrolyzes asparagine into aspartic acid and ammonia, is frequently used to treat acute lymphoblastic leukaemia in children. When combined with other chemotherapy drugs, the event-free survival rate is 90%. Due to immunogenicity and drug resistance, however, not all patients be...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929349/ https://www.ncbi.nlm.nih.gov/pubmed/36816964 http://dx.doi.org/10.3389/fonc.2023.1070069 |