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Optimization of CFTR gating through the evolution of its extracellular loops
CFTR chloride channel mutations cause the lethal and incurable disease cystic fibrosis (CF). CFTR is activated by phosphorylation, and phosphorylated channels exhibit “bursting” behavior—“bursts” of openings separated by short “flickery” closures and flanked by long “interburst” closures—driven by A...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929929/ https://www.ncbi.nlm.nih.gov/pubmed/36723516 http://dx.doi.org/10.1085/jgp.202213264 |