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Accurate Prediction of Enzyme Thermostabilization with Rosetta Using AlphaFold Ensembles

[Image: see text] Thermostability enhancement is a fundamental aspect of protein engineering as a biocatalyst’s half-life is key for its industrial and biotechnological application, particularly at high temperatures and under harsh conditions. Thermostability changes upon mutation originate from mod...

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Detalles Bibliográficos
Autores principales: Peccati, Francesca, Alunno-Rufini, Sara, Jiménez-Osés, Gonzalo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930118/
https://www.ncbi.nlm.nih.gov/pubmed/36647575
http://dx.doi.org/10.1021/acs.jcim.2c01083