Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch

Mechanosensitive PIEZO1 ion channels open in response to membrane stretch. Yet, the underlying microscopic mechanism of this activation remains unknown. To probe this mechanism, we used cell-attached pressure-clamp recordings to measure single channel currents at different steady-state negative pipe...

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Detalles Bibliográficos
Autores principales: Wijerathne, Tharaka D., Ozkan, Alper D., Lacroix, Jérôme J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930135/
https://www.ncbi.nlm.nih.gov/pubmed/36715688
http://dx.doi.org/10.1085/jgp.202213260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930135/
https://www.ncbi.nlm.nih.gov/pubmed/36715688
http://dx.doi.org/10.1085/jgp.202213260

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