Sporadic Creutzfeldt–Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice

Human cerebral organoids (COs) are three-dimensional self-organizing cultures of cerebral brain tissue differentiated from induced pluripotent stem cells. We have recently shown that COs are susceptible to infection with different subtypes of Creutzfeldt–Jakob disease (CJD) prions, which in humans c...

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Detalles Bibliográficos
Autores principales: Groveman, Bradley R., Race, Brent, Foliaki, Simote T., Williams, Katie, Hughson, Andrew G., Baune, Chase, Zanusso, Gianluigi, Haigh, Cathryn L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930245/
https://www.ncbi.nlm.nih.gov/pubmed/36788566
http://dx.doi.org/10.1186/s40478-023-01512-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930245/
https://www.ncbi.nlm.nih.gov/pubmed/36788566
http://dx.doi.org/10.1186/s40478-023-01512-1

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