A novel NRF2/ARE inhibitor gossypol induces cytotoxicity and sensitizes chemotherapy responses in chemo-refractory cancer cells

NRF2/ARE signaling pathway is a principal regulator of cellular redox homoeostasis. The stress-induced transcription factor, NRF2, can shield cells from the oxidative damages via binding to the consensus antioxidant-responsive element (ARE) and driving several cyto-protective genes expression. Incre...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Ya-Chu, Chang, Hsin-Huei, Chen, Huang-Hui, Yao, Jau-Ying, Chen, Yu-Tsen, Chuang, Yung-Jen, Chang, Jang-Yang, Kuo, Ching-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931009/
https://www.ncbi.nlm.nih.gov/pubmed/35649133
http://dx.doi.org/10.38212/2224-6614.3376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931009/
https://www.ncbi.nlm.nih.gov/pubmed/35649133
http://dx.doi.org/10.38212/2224-6614.3376

Ejemplares similares