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Convergent chemoenzymatic synthesis of O-GalNAc rare cores 5, 7, 8 and their sialylated forms

All O-GalNAc glycans are derived from 8 cores with 2 or 3 monosaccharides linked via α- or β-glycosidic bonds. While chemical and chemoenzymatic syntheses of β-linked cores 1–4 and 6 and derived glycans have been well developed, the preparation of α-linked rare cores 5, 7, and 8 is challenging due t...

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Detalles Bibliográficos
Autores principales: Gadi, Madhusudhan Reddy, Chen, Congcong, Bao, Shumin, Wang, Shuaishuai, Guo, Yuxi, Han, Jinghua, Xiao, Weidong, Li, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931048/
https://www.ncbi.nlm.nih.gov/pubmed/36819867
http://dx.doi.org/10.1039/d2sc06925c