Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation

Somatic activating mutations of PIK3CA are associated with development of vascular malformations (VMs). Here, we describe a microfluidic model of PIK3CA-driven VMs consisting of human umbilical vein endothelial cells expressing PIK3CA activating mutations embedded in three-dimensional hydrogels. We...

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Detalles Bibliográficos
Autores principales: Aw, Wen Yih, Cho, Crescentia, Wang, Hao, Cooper, Anne Hope, Doherty, Elizabeth L., Rocco, David, Huang, Stephanie A., Kubik, Sarah, Whitworth, Chloe P., Armstrong, Ryan, Hickey, Anthony J., Griffith, Boyce, Kutys, Matthew L., Blatt, Julie, Polacheck, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931220/
https://www.ncbi.nlm.nih.gov/pubmed/36791204
http://dx.doi.org/10.1126/sciadv.ade8939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931220/
https://www.ncbi.nlm.nih.gov/pubmed/36791204
http://dx.doi.org/10.1126/sciadv.ade8939

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