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Evolved bacterial resistance to the chemotherapy gemcitabine modulates its efficacy in co-cultured cancer cells

Drug metabolism by the microbiome can influence anticancer treatment success. We previously suggested that chemotherapies with antimicrobial activity can select for adaptations in bacterial drug metabolism that can inadvertently influence the host’s chemoresistance. We demonstrated that evolved resi...

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Detalles Bibliográficos
Autores principales: Sayin, Serkan, Rosener, Brittany, Li, Carmen G, Ho, Bao, Ponomarova, Olga, Ward, Doyle V, Walhout, Albertha JM, Mitchell, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931390/
https://www.ncbi.nlm.nih.gov/pubmed/36734518
http://dx.doi.org/10.7554/eLife.83140