Learn–confirm in model‐informed drug development: Assessing an immunogenicity quantitative systems pharmacology platform

Immunogenicity against therapeutic proteins frequently causes attrition owing to its potential impact on pharmacokinetics, pharmacodynamics, efficacy, and safety. Predicting immunogenicity is complex because of its multifactorial drivers, including compound properties, subject characteristics, and t...

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Detalles Bibliográficos
Autores principales: Franssen, Linnea C., Swat, Maciej J., Kierzek, Andrzej M., Rose, Rachel H., van der Graaf, Piet H., Grimm, Hans Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931426/
https://www.ncbi.nlm.nih.gov/pubmed/36418887
http://dx.doi.org/10.1002/psp4.12887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931426/
https://www.ncbi.nlm.nih.gov/pubmed/36418887
http://dx.doi.org/10.1002/psp4.12887

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