Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex

The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy(1). The phosphorylation of TFEB by the mechanistic target of rapamycin complex 1 (mTORC1)(2–5) is unique in its mTORC1 substrate recruitment mechanism, which is strictly dependent on the amino acid-mediated act...

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Detalles Bibliográficos
Autores principales: Cui, Zhicheng, Napolitano, Gennaro, de Araujo, Mariana E. G., Esposito, Alessandra, Monfregola, Jlenia, Huber, Lukas A., Ballabio, Andrea, Hurley, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931586/
https://www.ncbi.nlm.nih.gov/pubmed/36697823
http://dx.doi.org/10.1038/s41586-022-05652-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931586/
https://www.ncbi.nlm.nih.gov/pubmed/36697823
http://dx.doi.org/10.1038/s41586-022-05652-7

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