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Real-time denoising enables high-sensitivity fluorescence time-lapse imaging beyond the shot-noise limit
A fundamental challenge in fluorescence microscopy is the photon shot noise arising from the inevitable stochasticity of photon detection. Noise increases measurement uncertainty and limits imaging resolution, speed and sensitivity. To achieve high-sensitivity fluorescence imaging beyond the shot-no...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931589/ https://www.ncbi.nlm.nih.gov/pubmed/36163547 http://dx.doi.org/10.1038/s41587-022-01450-8 |