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Application of a physiologically based pharmacokinetic model in predicting captopril disposition in children with chronic kidney disease
Over the last several decades, angiotensin-converting enzyme inhibitors (ACEIs) have been a staple in the treatment of hypertension and renovascular disorders in children. One of the ACEIs, captopril, is projected to have all the benefits of traditional vasodilators. However, conducting clinical tri...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931704/ https://www.ncbi.nlm.nih.gov/pubmed/36792681 http://dx.doi.org/10.1038/s41598-023-29798-0 |