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Polygenic Risk Scores and the Need for Pharmacotherapy in Neonatal Abstinence Syndrome

OBJECTIVES: To identify genetic variants associated with NAS through a Genome Wide Association Study (GWAS) and estimate a Polygenic Risk Score (PRS) model for NAS. DESIGN: A prospective case-control study included 476 in-utero opioid-exposed term neonates. A GWAS of 1000 Genomes-imputed genotypes w...

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Detalles Bibliográficos
Autores principales:	Bibi, Shawana, Gaddis, Nathan, Johnson, Eric O., Lester, Barry M., Kraft, Walter, Singh, Rachana, Terrin, Norma, Adeniyi-Jones, Susan, Davis, Jonathan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931940/ https://www.ncbi.nlm.nih.gov/pubmed/35974158 http://dx.doi.org/10.1038/s41390-022-02243-0

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