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Developmental programming: adverse sexually dimorphic transcriptional programming of gestational testosterone excess in cardiac left ventricle of fetal sheep

Adverse in-utero insults during fetal life alters offspring’s developmental trajectory, including that of the cardiovascular system. Gestational hyperandrogenism is once such adverse in-utero insult. Gestational testosterone (T)-treatment, an environment of gestational hyperandrogenism, manifests as...

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Detalles Bibliográficos
Autores principales: Ramamoorthi Elangovan, Venkateswaran, Saadat, Nadia, Ghnenis, Adel, Padmanabhan, Vasantha, Vyas, Arpita K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932081/
https://www.ncbi.nlm.nih.gov/pubmed/36792653
http://dx.doi.org/10.1038/s41598-023-29212-9