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Evaluation of polyanionic cyclodextrins as high affinity binding scaffolds for fentanyl
Cyclodextrins (CDs) have been previously shown to display modest equilibrium binding affinities (K(a) ~ 100–200 M(-1)) for the synthetic opioid analgesic fentanyl. In this work, we describe the synthesis of new CDs possessing extended thioalkylcarboxyl or thioalkylhydroxyl moieties and assess their...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932099/ https://www.ncbi.nlm.nih.gov/pubmed/36792632 http://dx.doi.org/10.1038/s41598-023-29662-1 |