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Identifying a stable bulk dmLT adjuvant formulation at a clinically relevant concentration

Double mutant heat-labile toxin (dmLT) is a novel vaccine adjuvant under development with several different vaccine candidates. Studies using existing dmLT adjuvant stocks require significant dilution to achieve a clinically relevant dose. This dilution leads to wastage of the adjuvant. This manuscr...

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Detalles Bibliográficos
Autores principales: Estrada, Marcus R., Bzami, Anan, Norton, Elizabeth B., White, Jessica A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932622/
https://www.ncbi.nlm.nih.gov/pubmed/36658044
http://dx.doi.org/10.1016/j.vaccine.2023.01.005