Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion

Deletion of O-GlcNAc transferase (Ogt) in pancreatic epithelial progenitor cells results in pancreatic hypoplasia at birth, partly due to increased apoptosis during embryonic development. Constitutive loss of Ogt in β-cells results in increased ER stress and apoptosis, and in the Ogt-deficient pancr...

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Detalles Bibliográficos
Autores principales: Wong, Alicia, Pritchard, Samantha, Moore, Mackenzie, Akhaphong, Brian, Avula, Nandini, Beetch, Megan, Fujitani, Yoshio, Alejandro, Emilyn U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932656/
https://www.ncbi.nlm.nih.gov/pubmed/36623733
http://dx.doi.org/10.1016/j.jbc.2023.102878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932656/
https://www.ncbi.nlm.nih.gov/pubmed/36623733
http://dx.doi.org/10.1016/j.jbc.2023.102878

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