Sildenafil affects the human Kir2.1 and Kir2.2 channels at clinically relevant concentrations: Inhibition potentiated by low Ba(2+)

Sildenafil (Viagra), the first approved and widely used oral drug for the treatment of erectile dysfunction, was occasionally associated with life-threatening ventricular arrhythmias in patients. Since inward rectifier potassium current (I (K1)) may considerably contribute to this arrhythmogenesis,...

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Detalles Bibliográficos
Autores principales: Iijima, Akimasa, Švecová, Olga, Hošek, Jan, Kula, Roman, Bébarová, Markéta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932908/
https://www.ncbi.nlm.nih.gov/pubmed/36817146
http://dx.doi.org/10.3389/fphar.2023.1136272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932908/
https://www.ncbi.nlm.nih.gov/pubmed/36817146
http://dx.doi.org/10.3389/fphar.2023.1136272

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