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Evolution of nanobodies specific for BCL11A

Transcription factors (TFs) control numerous genes that are directly relevant to many human disorders. However, developing specific reagents targeting TFs within intact cells is challenging due to the presence of highly disordered regions within these proteins. Intracellular antibodies offer opportu...

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Detalles Bibliográficos
Autores principales: Yin, Maolu, Izadi, Manizheh, Tenglin, Karin, Viennet, Thibault, Zhai, Liting, Zheng, Ge, Arthanari, Haribabu, Dassama, Laura M. K., Orkin, Stuart H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933118/
https://www.ncbi.nlm.nih.gov/pubmed/36626555
http://dx.doi.org/10.1073/pnas.2218959120