prM-reactive antibodies reveal a role for partially mature virions in dengue virus pathogenesis

Cleavage of the flavivirus premembrane (prM) structural protein during maturation can be inefficient. The contribution of partially mature flavivirus virions that retain uncleaved prM to pathogenesis during primary infection is unknown. To investigate this question, we characterized the functional p...

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Detalles Bibliográficos
Autores principales: A. Dowd, Kimberly, Sirohi, Devika, D. Speer, Scott, VanBlargan, Laura A., Chen, Rita E., Mukherjee, Swati, Whitener, Bradley M., Govero, Jennifer, Aleshnick, Maya, Larman, Bridget, Sukupolvi-Petty, Soila, Sevvana, Madhumati, Miller, Andrew S., Klose, Thomas, Zheng, Aihua, Koenig, Scott, Kielian, Margaret, Kuhn, Richard J., Diamond, Michael S., Pierson, Theodore C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933121/
https://www.ncbi.nlm.nih.gov/pubmed/36638211
http://dx.doi.org/10.1073/pnas.2218899120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933121/
https://www.ncbi.nlm.nih.gov/pubmed/36638211
http://dx.doi.org/10.1073/pnas.2218899120

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