Screening method toward ClbP-specific inhibitors

BACKGROUND: Colibactin is a genotoxin produced by Escherichia coli and other Enterobacteriaceae that is believed to increase the risk of colorectal cancer (CRC) of their symbiosis hosts, including human. A peptidase ClbP is the key enzyme for activation of colibactin. Inhibition of ClbP is considere...

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Detalles Bibliográficos
Autores principales: Zhou, Tao, Ando, Takayuki, Kudo, Akihiro, Sato, Michio, Miyoshi, Noriyuki, Mutoh, Michihiro, Ishikawa, Hideki, Wakabayashi, Keiji, Watanabe, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933310/
https://www.ncbi.nlm.nih.gov/pubmed/36797758
http://dx.doi.org/10.1186/s41021-023-00264-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933310/
https://www.ncbi.nlm.nih.gov/pubmed/36797758
http://dx.doi.org/10.1186/s41021-023-00264-7

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