Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders

[Image: see text] Retinoic acid receptor-related orphan receptor γ-t (RORγt) and GPBAR1, a transmembrane G-protein-coupled receptor for bile acids, are attractive drug targets to develop clinically relevant small modulators as potent therapeutics for autoimmune diseases. Herein, we designed, synthes...

Descripción completa

Detalles Bibliográficos
Autores principales: Fiorillo, Bianca, Roselli, Rosalinda, Finamore, Claudia, Biagioli, Michele, di Giorgio, Cristina, Bordoni, Martina, Conflitti, Paolo, Marchianò, Silvia, Bellini, Rachele, Rapacciuolo, Pasquale, Cassiano, Chiara, Limongelli, Vittorio, Sepe, Valentina, Catalanotti, Bruno, Fiorucci, Stefano, Zampella, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933477/
https://www.ncbi.nlm.nih.gov/pubmed/36816679
http://dx.doi.org/10.1021/acsomega.2c07907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933477/
https://www.ncbi.nlm.nih.gov/pubmed/36816679
http://dx.doi.org/10.1021/acsomega.2c07907

Ejemplares similares