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Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders

[Image: see text] Retinoic acid receptor-related orphan receptor γ-t (RORγt) and GPBAR1, a transmembrane G-protein-coupled receptor for bile acids, are attractive drug targets to develop clinically relevant small modulators as potent therapeutics for autoimmune diseases. Herein, we designed, synthes...

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Detalles Bibliográficos
Autores principales:	Fiorillo, Bianca, Roselli, Rosalinda, Finamore, Claudia, Biagioli, Michele, di Giorgio, Cristina, Bordoni, Martina, Conflitti, Paolo, Marchianò, Silvia, Bellini, Rachele, Rapacciuolo, Pasquale, Cassiano, Chiara, Limongelli, Vittorio, Sepe, Valentina, Catalanotti, Bruno, Fiorucci, Stefano, Zampella, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933477/ https://www.ncbi.nlm.nih.gov/pubmed/36816679 http://dx.doi.org/10.1021/acsomega.2c07907

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