Polynorbornene-based bioconjugates by aqueous grafting-from ring-opening metathesis polymerization reduce protein immunogenicity

Protein-polymer conjugates (PPCs) improve therapeutic efficacy of proteins and have been widely used for the treatment of various diseases such as cancer, diabetes, and hepatitis. PEGylation is considered as the “gold standard” in bioconjugation, although in practice its clinical applications are be...

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Detalles Bibliográficos
Autores principales: Church, Derek C., Davis, Elizabathe, Caparco, Adam A., Takiguchi, Lauren, Chung, Young Hun, Steinmetz, Nicole F., Pokorski, Jonathan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933924/
https://www.ncbi.nlm.nih.gov/pubmed/36816463
http://dx.doi.org/10.1016/j.xcrp.2022.101067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933924/
https://www.ncbi.nlm.nih.gov/pubmed/36816463
http://dx.doi.org/10.1016/j.xcrp.2022.101067

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