MCL-1 is a master regulator of cancer dependency on fatty acid oxidation

MCL-1 is an anti-apoptotic BCL-2 family protein essential for survival of diverse cell types and is a major driver of cancer and chemoresistance. The mechanistic basis for the oncogenic supremacy of MCL-1 among its anti-apoptotic homologs is unclear and implicates physiologic roles of MCL-1 beyond a...

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Detalles Bibliográficos
Autores principales: Prew, Michelle S., Adhikary, Utsarga, Choi, Dong Wook, Portero, Erika P., Paulo, Joao A., Gowda, Pruthvi, Budhraja, Amit, Opferman, Joseph T., Gygi, Steven P., Danial, Nika N., Walensky, Loren D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933948/
https://www.ncbi.nlm.nih.gov/pubmed/36198266
http://dx.doi.org/10.1016/j.celrep.2022.111445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933948/
https://www.ncbi.nlm.nih.gov/pubmed/36198266
http://dx.doi.org/10.1016/j.celrep.2022.111445

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