Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs

CAG trinucleotide repeat expansions cause several neurodegenerative diseases, including Huntington's disease and spinocerebellar ataxia. RNAs with expanded CAG repeats contribute to disease in two unusual ways. First, these repeat-containing RNAs may agglomerate in the nucleus as foci that sequ...

Descripción completa

Detalles Bibliográficos
Autores principales: Das, Michael R., Chang, Yeonji, Anderson, Rachel, Saunders, Reuben A., Zhang, Nan, Tomberlin, Colson P., Vale, Ronald D., Jain, Ankur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934169/
https://www.ncbi.nlm.nih.gov/pubmed/36623192
http://dx.doi.org/10.1073/pnas.2215071120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934169/
https://www.ncbi.nlm.nih.gov/pubmed/36623192
http://dx.doi.org/10.1073/pnas.2215071120

Ejemplares similares