Cytosolic condensates rich in polyserine define subcellular sites of tau aggregation

Tau aggregates are a hallmark of multiple neurodegenerative diseases and can contain RNAs and RNA-binding proteins, including serine/arginine repetitive matrix protein 2 (SRRM2) and pinin (PNN). However, how these nuclear proteins mislocalize and their influence on the prion-like propagation of tau...

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Detalles Bibliográficos
Autores principales: Lester, Evan, Van Alstyne, Meaghan, McCann, Kathleen L., Reddy, Spoorthy, Cheng, Li Yi, Kuo, Jeff, Pratt, James, Parker, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934293/
https://www.ncbi.nlm.nih.gov/pubmed/36626563
http://dx.doi.org/10.1073/pnas.2217759120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934293/
https://www.ncbi.nlm.nih.gov/pubmed/36626563
http://dx.doi.org/10.1073/pnas.2217759120

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