Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity

A small proportion of multiple sclerosis (MS) patients develop new disease activity soon after starting anti-CD20 therapy. This activity does not recur with further dosing, possibly reflecting deeper depletion of CD20-expressing cells with repeat infusions. We assessed cellular immune profiles and t...

Descripción completa

Detalles Bibliográficos
Autores principales: Shinoda, Koji, Li, Rui, Rezk, Ayman, Mexhitaj, Ina, Patterson, Kristina R., Kakara, Mihir, Zuroff, Leah, Bennett, Jeffrey L., von Büdingen, H.-Christian, Carruthers, Robert, Edwards, Keith R., Fallis, Robert, Giacomini, Paul S., Greenberg, Benjamin M., Hafler, David A., Ionete, Carolina, Kaunzner, Ulrike W., Lock, Christopher B., Longbrake, Erin E., Pardo, Gabriel, Piehl, Fredrik, Weber, Martin S., Ziemssen, Tjalf, Jacobs, Dina, Gelfand, Jeffrey M., Cross, Anne H., Cameron, Briana, Musch, Bruno, Winger, Ryan C., Jia, Xiaoming, Harp, Christopher T., Herman, Ann, Bar-Or, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934304/
https://www.ncbi.nlm.nih.gov/pubmed/36634138
http://dx.doi.org/10.1073/pnas.2207291120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934304/
https://www.ncbi.nlm.nih.gov/pubmed/36634138
http://dx.doi.org/10.1073/pnas.2207291120

Ejemplares similares