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Differential modularity of the mammalian Engrailed 1 enhancer network directs sweat gland development

Enhancers are context-specific regulators of expression that drive biological complexity and variation through the redeployment of conserved genes. An example of this is the enhancer-mediated control of Engrailed 1 (EN1), a pleiotropic gene whose expression is required for the formation of mammalian...

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Detalles Bibliográficos
Autores principales: Aldea, Daniel, Kokalari, Blerina, Atsuta, Yuji, Dingwall, Heather L., Zheng, Ying, Nace, Arben, Cotsarelis, George, Kamberov, Yana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934363/
https://www.ncbi.nlm.nih.gov/pubmed/36745673
http://dx.doi.org/10.1371/journal.pgen.1010614