Characterizing the consensus residue specificity and surface of BCL-2 binding to BH3 ligands using the Knob-Socket model

Cancer cells bypass cell death by changing the expression of the BCL-2 family of proteins, which are apoptotic pathway regulators. Upregulation of pro-survival BCL-2 proteins or downregulation of cell death effectors BAX and BAK interferes with the initiation of the intrinsic apoptotic pathway. In n...

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Detalles Bibliográficos
Autores principales: Yi, Jennifer, Kellner, Vivian, Joo, Hyun, Chien, Nathaniel, Patel, Shivarni, Chaban, Zaina, Tsai, Jerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934389/
https://www.ncbi.nlm.nih.gov/pubmed/36795726
http://dx.doi.org/10.1371/journal.pone.0281463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934389/
https://www.ncbi.nlm.nih.gov/pubmed/36795726
http://dx.doi.org/10.1371/journal.pone.0281463

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