Setup of human liver-chips integrating 3D models, microwells and a standardized microfluidic platform as proof-of-concept study to support drug evaluation

Human 3D liver microtissues/spheroids are powerful in vitro models to study drug-induced liver injury (DILI) but the small number of cells per spheroid limits the models’ usefulness to study drug metabolism. In this work, we scale up the number of spheroids on both a plate and a standardized organ-c...

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Detalles Bibliográficos
Autores principales: Cox, Benoit, Barton, Patrick, Class, Reiner, Coxhead, Hannah, Delatour, Claude, Gillent, Eric, Henshall, Jamie, Isin, Emre M., King, Lloyd, Valentin, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934436/
https://www.ncbi.nlm.nih.gov/pubmed/36824483
http://dx.doi.org/10.1016/j.bbiosy.2022.100054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934436/
https://www.ncbi.nlm.nih.gov/pubmed/36824483
http://dx.doi.org/10.1016/j.bbiosy.2022.100054

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