Cargando…

Diminishing neuronal acidification by channelrhodopsins with low proton conduction

Many channelrhodopsins are permeable to protons. We found that in neurons, activation of a highcurrent channelrhodopsin, CheRiff, led to significant acidification, with faster acidification in the dendrites than in the soma. Experiments with patterned optogenetic stimulation in monolayers of HEK cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Hayward, Rebecca Frank, Brooks, F. Phil, Yang, Shang, Gao, Shiqiang, Cohen, Adam E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934520/
https://www.ncbi.nlm.nih.gov/pubmed/36798192
http://dx.doi.org/10.1101/2023.02.07.527404