Cargando…

TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy

Transcription factor EB (TFEB) mediates gene expression through binding to the Coordinated Lysosome Expression And Regulation (CLEAR) sequence. TFEB targets include subunits of the vacuolar ATPase (v-ATPase) essential for lysosome acidification. Single nucleus RNA-sequencing (snRNA-seq) of wild-type...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Baiping, Martini-Stoica, Heidi, Qi, Chuangye, Lu, Tzu-Chiao, Wang, Shuo, Xiong, Wen, Qi, Yanyan, Xu, Yin, Sardiello, Marco, Li, Hongjie, Zheng, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934527/ https://www.ncbi.nlm.nih.gov/pubmed/36798205 http://dx.doi.org/10.1101/2023.02.06.527293

Ejemplares similares

Vacuolar-type ATPase: A proton pump to lysosomal trafficking
por: FUTAI, Masamitsu, et al.
Publicado: (2019)

The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases
por: Song, Qiaoyun, et al.
Publicado: (2020)

Acidification of the lysosome-like vacuole and the vacuolar H+-ATPase are deficient in two yeast mutants that fail to sort vacuolar proteins
Publicado: (1989)

STAT3 associates with vacuolar H(+)-ATPase and regulates cytosolic and lysosomal pH
por: Liu, Bin, et al.
Publicado: (2018)

A seeding based cellular assay of tauopathy
por: Xu, Yin, et al.
Publicado: (2016)

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading
por: Martini-Stoica, Heidi, et al.
Publicado: (2018)

Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster
por: Tognon, Emiliana, et al.
Publicado: (2016)

TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits12
por: Wang, Hongjie, et al.
Publicado: (2016)

Curcumin targets the TFEB-lysosome pathway for induction of autophagy
por: Zhang, Jianbin, et al.
Publicado: (2016)

Docetaxel enhances lysosomal function through TFEB activation
por: Zhang, Jianbin, et al.
Publicado: (2018)

TFEB‐dependent lysosome biogenesis is required for senescence
por: Curnock, Rachel, et al.
Publicado: (2023)

Regulation of TFEB and V-ATPases by mTORC1
por: Peña-Llopis, Samuel, et al.
Publicado: (2011)

LRRK2 interacts with the vacuolar-type H(+)-ATPase pump a1 subunit to regulate lysosomal function
por: Wallings, Rebecca, et al.
Publicado: (2019)

TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator
por: Franco-Juárez, Berenice, et al.
Publicado: (2022)

Role of the vacuolar ATPase in the Alphavirus replication cycle
por: Schuchman, Ryan M., et al.
Publicado: (2018)

Lysosomal calcium signaling regulates autophagy via calcineurin and TFEB
por: Medina, Diego L., et al.
Publicado: (2015)

Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia
por: Bao, Jintao, et al.
Publicado: (2016)

Pomegranate activates TFEB to promote autophagy-lysosomal fitness and mitophagy
por: Tan, Sijie, et al.
Publicado: (2019)

Coxsackievirus B3 targets TFEB to disrupt lysosomal function
por: Mohamud, Yasir, et al.
Publicado: (2021)

Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB
por: Wang, Yusha, et al.
Publicado: (2019)

RNA Interference of Genes Encoding the Vacuolar-ATPase in Liriomyza trifolii
por: Chang, Ya-Wen, et al.
Publicado: (2021)

Flexibility within the Rotor and Stators of the Vacuolar H(+)-ATPase
por: Song, Chun Feng, et al.
Publicado: (2013)

Rotating with the brakes on and other unresolved features of the vacuolar ATPase
por: Rawson, Shaun, et al.
Publicado: (2016)

The curious case of vacuolar ATPase: regulation of signaling pathways
por: Pamarthy, Sahithi, et al.
Publicado: (2018)

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
por: Settembre, Carmine, et al.
Publicado: (2012)

Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy
por: Hayek, Summer R., et al.
Publicado: (2014)

CDK4/6 regulate lysosome biogenesis through TFEB/TFE3
por: Yin, Qiuyuan, et al.
Publicado: (2020)

Lysosomal and vacuolar sorting: not so different after all!
por: de Marcos Lousa, Carine, et al.
Publicado: (2016)

Material properties of phase-separated TFEB condensates regulate the autophagy-lysosome pathway
por: Wang, Zheng, et al.
Publicado: (2022)

Identification of a five-gene signature deriving from the vacuolar ATPase (V-ATPase) sub-classifies gliomas and decides prognoses and immune microenvironment alterations
por: Qi, Chunxiao, et al.
Publicado: (2022)

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes
por: Young, Nathan P., et al.
Publicado: (2016)

TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin
por: Moruno Manchon, Jose Felix, et al.
Publicado: (2016)

TFEB Dependent Autophagy-Lysosomal Pathway: An Emerging Pharmacological Target in Sepsis
por: Liu, Xin, et al.
Publicado: (2021)

Over-Mutated Mitochondrial, Lysosomal and TFEB-Regulated Genes in Parkinson’s Disease
por: Segur-Bailach, Eulàlia, et al.
Publicado: (2022)

Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex
por: Cui, Zhicheng, et al.
Publicado: (2023)

TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes
por: Willett, Rose, et al.
Publicado: (2017)

TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer
por: Zhao, Ben, et al.
Publicado: (2020)

An isoform of the vacuolar (H(+))-ATPase accessory subunit Ac45
por: Jansen, Eric J. R., et al.
Publicado: (2009)

The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma
por: Di Cristofori, Andrea, et al.
Publicado: (2015)

Cryo-EM studies of the structure and dynamics of vacuolar-type ATPases
por: Mazhab-Jafari, Mohammad T., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_fcb62b2c0s98evpfl9vl770m7c