Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscle and Structure Activity Relationship

Despite large investments from academia and industry, heart failure, which results from a disruption of the contractile apparatus, remains a leading cause of death. Cardiac muscle contraction is a calcium-dependent mechanism, which is regulated by the troponin protein complex (cTn) and specifically...

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Detalles Bibliográficos
Autores principales: Hantz, Eric R., Tikunova, Svetlana B., Belevych, Natalya, Davis, Jonathan P., Reiser, Peter J., Lindert, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934531/
https://www.ncbi.nlm.nih.gov/pubmed/36798160
http://dx.doi.org/10.1101/2023.02.06.527323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934531/
https://www.ncbi.nlm.nih.gov/pubmed/36798160
http://dx.doi.org/10.1101/2023.02.06.527323

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