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Inhaled CpG increases survival and synergizes with checkpoint inhibition in lymphangioleiomyomatosis

RATIONALE: Lymphangioleiomyomatosis (LAM) is a devastating disease primarily found in women of reproductive age that leads to cancer-like cystic destruction of the lungs. Recent work has shown that LAM causes immunosuppression and that checkpoint inhibitors can be used as LAM treatment. IN lung canc...

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Detalles Bibliográficos
Autores principales: Amosu, Mayowa M, McCright, Jacob C, Yang, Bennett E, de Oro Fernandez, Juan Grano, Moore, Kaitlyn A, Gadde, Havish S, Kaluzienski, Michele L, Maisel, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934559/
https://www.ncbi.nlm.nih.gov/pubmed/36798234
http://dx.doi.org/10.1101/2023.02.06.527331