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Metabolic modeling of sex-specific tissue predicts mechanisms of differences in toxicological responses
Male subjects in animal and human studies are disproportionately used for toxicological testing. This discrepancy is evidenced in clinical medicine where females are more likely than males to experience liver-related adverse events in response to xenobiotics. While previous work has shown gene expre...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934589/ https://www.ncbi.nlm.nih.gov/pubmed/36798158 http://dx.doi.org/10.1101/2023.02.07.527430 |