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The landscape of MHC-presented phosphopeptides yields actionable shared tumor antigens for cancer immunotherapy across multiple HLA alleles

BACKGROUND: Certain phosphorylated peptides are differentially presented by MHC molecules on cancer cells characterized by aberrant phosphorylation. Phosphopeptides presented in complex with the human leukocyte antigen HLA-A*02:01 provide a stability advantage over their nonphosphorylated counterpar...

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Detalles Bibliográficos
Autores principales: Molvi, Zaki, Klatt, Martin G., Dao, Tao, Urraca, Jessica, Scheinberg, David A., O’Reilly, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934604/
https://www.ncbi.nlm.nih.gov/pubmed/36798179
http://dx.doi.org/10.1101/2023.02.08.527552