CPA-Perturb-seq: Multiplexed single-cell characterization of alternative polyadenylation regulators

Most mammalian genes have multiple polyA sites, representing a substantial source of transcript diversity that is governed by the cleavage and polyadenylation (CPA) regulatory machinery. To better understand how these proteins govern polyA site choice we introduce CPA-Perturb-seq, a multiplexed pert...

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Detalles Bibliográficos
Autores principales: Kowalski, Madeline H., Wessels, Hans-Hermann, Linder, Johannes, Choudhary, Saket, Hartman, Austin, Hao, Yuhan, Mascio, Isabella, Dalgarno, Carol, Kundaje, Anshul, Satija, Rahul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934614/
https://www.ncbi.nlm.nih.gov/pubmed/36798324
http://dx.doi.org/10.1101/2023.02.09.527751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934614/
https://www.ncbi.nlm.nih.gov/pubmed/36798324
http://dx.doi.org/10.1101/2023.02.09.527751

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