Interference with the HNF4-dependent gene regulatory network diminishes ER stress in hepatocytes

In all eukaryotic cell types, the unfolded protein response (UPR) upregulates factors that promote protein folding and misfolded protein clearance to help alleviate endoplasmic reticulum (ER) stress. Yet ER stress in the liver is uniquely accompanied by the suppression of metabolic genes, the coordi...

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Detalles Bibliográficos
Autores principales: Shah, Anit, Huck, Ian, Duncan, Kaylia, Gansemer, Erica R., Apte, Udayan, Stamnes, Mark A., Rutkowski, D. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934629/
https://www.ncbi.nlm.nih.gov/pubmed/36798396
http://dx.doi.org/10.1101/2023.02.09.527889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934629/
https://www.ncbi.nlm.nih.gov/pubmed/36798396
http://dx.doi.org/10.1101/2023.02.09.527889

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