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Interference with the HNF4-dependent gene regulatory network diminishes ER stress in hepatocytes
In all eukaryotic cell types, the unfolded protein response (UPR) upregulates factors that promote protein folding and misfolded protein clearance to help alleviate endoplasmic reticulum (ER) stress. Yet ER stress in the liver is uniquely accompanied by the suppression of metabolic genes, the coordi...
Autores principales: | Shah, Anit, Huck, Ian, Duncan, Kaylia, Gansemer, Erica R., Apte, Udayan, Stamnes, Mark A., Rutkowski, D. Thomas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934629/ https://www.ncbi.nlm.nih.gov/pubmed/36798396 http://dx.doi.org/10.1101/2023.02.09.527889 |
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