Multivariate adaptive shrinkage improves cross-population transcriptome prediction for transcriptome-wide association studies in underrepresented populations

Transcriptome prediction models built with data from European-descent individuals are less accurate when applied to different populations because of differences in linkage disequilibrium patterns and allele frequencies. We hypothesized methods that leverage shared regulatory effects across different...

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Detalles Bibliográficos
Autores principales: Araujo, Daniel S., Nguyen, Chris, Hu, Xiaowei, Mikhaylova, Anna V., Gignoux, Chris, Ardlie, Kristin, Taylor, Kent D., Durda, Peter, Liu, Yongmei, Papanicolaou, George, Cho, Michael H., Rich, Stephen S., Rotter, Jerome I., Im, Hae Kyung, Manichaikul, Ani, Wheeler, Heather E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934635/
https://www.ncbi.nlm.nih.gov/pubmed/36798214
http://dx.doi.org/10.1101/2023.02.09.527747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934635/
https://www.ncbi.nlm.nih.gov/pubmed/36798214
http://dx.doi.org/10.1101/2023.02.09.527747

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