Sex-specific declines in cholinergic-targeting tRNA fragments in the nucleus accumbens in Alzheimer’s disease

INTRODUCTION: Females with Alzheimer’s disease (AD) suffer accelerated dementia and loss of cholinergic neurons compared to males, but the underlying mechanisms are unknown. Seeking causal contributors to both these phenomena, we pursued changes in tRNA fragments (tRFs) targeting cholinergic transcr...

Descripción completa

Detalles Bibliográficos
Autores principales: Shulman, Dana, Dubnov, Serafima, Zorbaz, Tamara, Madrer, Nimrod, Paldor, Iddo, Bennett, David A., Seshadri, Sudha, Mufson, Elliott J., Greenberg, David S., Loewenstein, Yonatan, Soreq, Hermona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934682/
https://www.ncbi.nlm.nih.gov/pubmed/36798311
http://dx.doi.org/10.1101/2023.02.08.527612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934682/
https://www.ncbi.nlm.nih.gov/pubmed/36798311
http://dx.doi.org/10.1101/2023.02.08.527612

Ejemplares similares