PI3Kδ inhibition potentiates glucocorticoids in B-lymphoblastic leukemia by decreasing receptor phosphorylation and enhancing gene regulation

Glucocorticoids, including dexamethasone and prednisone, are the cornerstone of B-lymphoblastic leukemia (B-ALL) therapy. Because response to glucocorticoids alone predicts overall outcomes for B-ALL, enhancing glucocorticoid potency is a route to improving outcomes. However, systematic toxicities p...

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Detalles Bibliográficos
Autores principales: Zimmerman, Jessica A.O., Fang, Mimi, Pufall, Miles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934697/
https://www.ncbi.nlm.nih.gov/pubmed/36798391
http://dx.doi.org/10.1101/2023.02.10.527869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934697/
https://www.ncbi.nlm.nih.gov/pubmed/36798391
http://dx.doi.org/10.1101/2023.02.10.527869

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