Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization

Uterine fibroid (UF) tumors originate from a mutated smooth muscle cell (SMC). Nearly 70% of these tumors are driven by hotspot recurrent somatic mutations in the MED12 gene; however, there are no tractable genetic models to study the biology of UF tumors because, under culture conditions, the non-m...

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Detalles Bibliográficos
Autores principales: Buyukcelebi, Kadir, Chen, Xintong, Abdula, Fatih, Duval, Alexander, Ozturk, Harun, Seker-Polat, Fidan, Jin, Qiushi, Yin, Ping, Feng, Yue, Wei, Jian-Jun, Bulun, Serdar, Yue, Feng, Adli, Mazhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934745/
https://www.ncbi.nlm.nih.gov/pubmed/36798375
http://dx.doi.org/10.21203/rs.3.rs-2537075/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934745/
https://www.ncbi.nlm.nih.gov/pubmed/36798375
http://dx.doi.org/10.21203/rs.3.rs-2537075/v1

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