Cargando…

Blocking muscle wasting via deletion of the muscle specific E3 ubiquitin ligase MuRF1 impedes pancreatic tumor growth

Cancer-induced muscle wasting reduces quality of life, complicates or precludes cancer treatments, and predicts early mortality. Herein, we investigated the requirement of the muscle-specific E3 ubiquitin ligase, MuRF1, for muscle wasting induced by pancreatic cancer. Murine pancreatic cancer (KPC)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Neyroud, Daria, Laitano, Orlando, Daguspta, Aneesha, Lopez, Christopher, Schmitt, Rebecca E., Schneider, Jessica Z., Hammers, David W., Sweeney, H. Lee, Walter, Glenn A, Doles, Jason, Judge, Sarah M., Judge, Andrew R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934780/ https://www.ncbi.nlm.nih.gov/pubmed/36798266 http://dx.doi.org/10.21203/rs.3.rs-2524562/v1

Ejemplares similares

Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth
por: Neyroud, Daria, et al.
Publicado: (2023)

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2
por: Witt, Christian C, et al.
Publicado: (2008)

Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice
por: Labeit, Siegfried, et al.
Publicado: (2010)

Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model
por: Nguyen, Thanh, et al.
Publicado: (2020)

MuRF1/TRIM63, Master Regulator of Muscle Mass
por: Peris-Moreno, Dulce, et al.
Publicado: (2020)

Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice
por: Oakley, Robert H., et al.
Publicado: (2018)

Developmental regulation of MURF E3 ubiquitin ligases in skeletal muscle
por: Perera, Sue, et al.
Publicado: (2012)

Rare Variants in Genes Encoding MuRF1 and MuRF2 Are Modifiers of Hypertrophic Cardiomyopathy
por: Su, Ming, et al.
Publicado: (2014)

The E3 ligase MuRF2 plays a key role in the functional capacity of skeletal muscle fibroblasts
por: Silvestre, J.G., et al.
Publicado: (2019)

Noninvasive Imaging of In Vivo MuRF1 Expression during Muscle Atrophy
por: Li, Wei, et al.
Publicado: (2014)

Identification of the MuRF1 Skeletal Muscle Ubiquitylome Through Quantitative Proteomics
por: Baehr, Leslie M, et al.
Publicado: (2021)

Skeletal Muscle 11beta-HSD1 Controls Glucocorticoid-Induced Proteolysis and Expression of E3 Ubiquitin Ligases Atrogin-1 and MuRF-1
por: Biedasek, Katrin, et al.
Publicado: (2011)

A muscle‐specific MuRF1‐E2 network requires stabilization of MuRF1‐E2 complexes by telethonin, a newly identified substrate
por: Polge, Cécile, et al.
Publicado: (2017)

Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1
por: Franke, Barbara, et al.
Publicado: (2014)

Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic Mice with Small Molecules Targeting MuRF1
por: Labeit, Siegfried, et al.
Publicado: (2021)

The E3 ubiquitin ligase MuRF2 attenuates LPS‐induced macrophage activation by inhibiting production of inflammatory cytokines and migration
por: Bian, Hongjun, et al.
Publicado: (2018)

Muscle hypertrophy is associated with increases in proteasome activity that is independent of MuRF1 and MAFbx expression
por: Baehr, Leslie M., et al.
Publicado: (2014)

Imoxin attenuates LPS‐induced inflammation and MuRF1 expression in mouse skeletal muscle
por: Valentine, Rudy J., et al.
Publicado: (2018)

Sabinene Prevents Skeletal Muscle Atrophy by Inhibiting the MAPK–MuRF-1 Pathway in Rats
por: Ryu, Yunkyoung, et al.
Publicado: (2019)

Expanding the MuRF1 Universe with Quantitative Ubiquitylomics
por: Goodman, Craig A, et al.
Publicado: (2021)

Small‐molecule‐mediated chemical knock‐down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure
por: Adams, Volker, et al.
Publicado: (2019)

The Posterior Cricoarytenoid Muscle Is Spared from MuRF1-Mediated Muscle Atrophy in Mice with Acute Lung Injury
por: Files, D. Clark, et al.
Publicado: (2014)

Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass
por: Consitt, Leslie A., et al.
Publicado: (2017)

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation
por: Cohen, Shenhav, et al.
Publicado: (2009)

TRIM63 (MuRF-1) gene polymorphism is associated with biomarkers of exercise-induced muscle damage
por: Baumert, P., et al.
Publicado: (2018)

Small‐molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia
por: Bowen, Thomas Scott, et al.
Publicado: (2017)

Skeletal Muscle Stromal Cells Derived From MuRF1 Knockout Mice Are Resistant to Adipogenesis
por: Norman, Jennifer Elise, et al.
Publicado: (2021)

The Effects of Diet Induced Obesity (DIO) on Skeletal Muscle Transcription in MuRF1 KO Mice
por: Marshall, Andrea Gail, et al.
Publicado: (2021)

Excessive glucocorticoid-induced muscle MuRF1 overexpression is independent of Akt/FoXO1 pathway
por: Wang, Xiao Juan, et al.
Publicado: (2017)

Removal of MuRF1 Increases Muscle Mass in Nemaline Myopathy Models, but Does Not Provide Functional Benefits
por: Lindqvist, Johan, et al.
Publicado: (2022)

Lysine 222 in PPAR γ1 functions as the key site of MuRF2-mediated ubiquitination modification
por: Fan, Yucheng, et al.
Publicado: (2023)

MuRF-1 and Atrogin-1 Protein Expression and Quadriceps Fiber Size and Muscle Mass in Stable Patients with COPD
por: Natanek, Samantha A., et al.
Publicado: (2013)

Regulation of nicotinic acetylcholine receptor turnover by MuRF1 connects muscle activity to endo/lysosomal and atrophy pathways
por: Rudolf, Rüdiger, et al.
Publicado: (2012)

Differences in the Role of HDACs 4 and 5 in the Modulation of Processes Regulating MAFbx and MuRF1 Expression during Muscle Unloading
por: Mochalova, Ekaterina P., et al.
Publicado: (2020)

Supplementation of carnitine leads to an activation of the IGF-1/PI3K/Akt signalling pathway and down regulates the E3 ligase MuRF1 in skeletal muscle of rats
por: Keller, Janine, et al.
Publicado: (2013)

Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle
por: Pretto, Francesca, et al.
Publicado: (2014)

Chinese Herbal Medicine Baoyuan Jiedu Decoction Inhibited Muscle Atrophy of Cancer Cachexia through Atrogin-l and MuRF-1
por: Zhang, YaNan, et al.
Publicado: (2017)

Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space
por: Cadena, Samuel M., et al.
Publicado: (2019)

Muscle RING-finger protein-1 (MuRF1) functions and cellular localization are regulated by SUMO1 post-translational modification
por: Heras, Gabriel, et al.
Publicado: (2018)

Correction: Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle
por: Pretto, Francesca, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_9cj7dfd33vnf0vat0dn7k2lsg9