Epistatic Features and Machine Learning Improve Alzheimer’s Risk Prediction Over Polygenic Risk Scores

BACKGROUND. Polygenic risk scores (PRS) are linear combinations of genetic markers weighted by effect size that are commonly used to predict disease risk. For complex heritable diseases such as late onset Alzheimer’s disease (LOAD), PRS models fail to capture much of the heritability. Additionally,...

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Detalles Bibliográficos
Autores principales: Hermes, Stephen, Cady, Janet, Armentrout, Steven, O’Connor, James, Carlson, Sarah, Cruchaga, Carlos, Wingo, Thomas, Greytak, Ellen McRae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934790/
https://www.ncbi.nlm.nih.gov/pubmed/36798198
http://dx.doi.org/10.1101/2023.02.10.23285766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934790/
https://www.ncbi.nlm.nih.gov/pubmed/36798198
http://dx.doi.org/10.1101/2023.02.10.23285766

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