A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein

Phenotypic cell-based screens are critical tools for discovering candidate drugs for development, yet identification of the cellular target and mode of action of a candidate drug is often lacking. Using an imaging-based screen, we recently discovered an N-[(4-hydroxychroman-4-yl)methyl]-sulphonamide...

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Detalles Bibliográficos
Autores principales: Yahiya, Sabrina, Saunders, Charlie N., Hassan, Sarah, Straschil, Ursula, Fischer, Oliver J., Rueda-Zubiaurre, Ainoa, Haase, Silvia, Vizcay-Barrena, Gema, Famodimu, Mufuliat Toyin, Jordan, Sarah, Delves, Michael J., Tate, Edward W., Barnard, Anna, Fuchter, Matthew J., Baum, Jake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934914/
https://www.ncbi.nlm.nih.gov/pubmed/36715290
http://dx.doi.org/10.1242/dmm.049950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934914/
https://www.ncbi.nlm.nih.gov/pubmed/36715290
http://dx.doi.org/10.1242/dmm.049950

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