Human DNA-dependent protein kinase activation mechanism

DNA-dependent protein kinase (DNA-PK), a multicomponent complex including the DNA-PK catalytic subunit and Ku70/80 heterodimer together with DNA, is central to human DNA damage response and repair. Using a DNA-PK-selective inhibitor (M3814), we identified from one dataset two cryo-EM structures of t...

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Detalles Bibliográficos
Autores principales: Liang, Shikang, Blundell, Tom L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935390/
https://www.ncbi.nlm.nih.gov/pubmed/36604499
http://dx.doi.org/10.1038/s41594-022-00881-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935390/
https://www.ncbi.nlm.nih.gov/pubmed/36604499
http://dx.doi.org/10.1038/s41594-022-00881-w

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