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Brominated lipid probes expose structural asymmetries in constricted membranes

Lipids in biological membranes are thought to be functionally organized, but few experimental tools can probe nanoscale membrane structure. Using brominated lipids as contrast probes for cryo-EM and a model ESCRT-III membrane-remodeling system composed of human CHMP1B and IST1, we observed leaflet-l...

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Detalles Bibliográficos
Autores principales: Moss, Frank R., Lincoff, James, Tucker, Maxwell, Mohammed, Arshad, Grabe, Michael, Frost, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935397/
https://www.ncbi.nlm.nih.gov/pubmed/36624348
http://dx.doi.org/10.1038/s41594-022-00898-1